LD50 of Cannabis

The estimated LD-50 (lethal threshold) for marijuana,established in 1988 by the DEA’s appropriate fact-finder, is 1:20,000 or 1:40,000.

Quote:

At present it is estimated that marijuana’s LD-50 is around1:20,000 or 1:40,000. In layman terms this means that in order to induce death a marijuana smoker would have to consume 20,000 to 40,000 times as much marijuana as is contained in one marijuana cigarette. NIDA-supplied marijuana cigarettes weigh approximately .9 grams. A smoker would theoretically have to consume nearly 1,500 pounds of marijuana within about fifteen minutes to induce a lethal response.

cannabis-science.com/content/DEA%20Ruling%20Judge%20Young.pdf

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Note: In Judge Young’s report cannabis is referred to as marijuana

UNITED STATES DEPARTMENT OF JUSTICE
Drug Enforcement Administration
_______________________________________
)
In The Matter Of
)
)
Docket No. 86-22
MARIJUANA RESCHEDULING PETITION )
_______________________________________)
OPINION AND RECOMMENDED RULING, FINDINGS OF
FACT, CONCLUSIONS OF LAW AND DECISION OF
Administrative LAW JUDGE.
FRANCIS L. YOUNG, Administrative Law Judge
DATED: SEP 6 1988

FRANCIS L. YOUNG, Administrative Law Judge

……………………

Part VIII.

ACCEPTED SAFETY FOR USE UNDER MEDICAL SUPERVISION

With respect to whether or not there is “a lack of accepted safety
for use of [marijuana] under medical supervision”, the record shows the
following facts to be uncontroverted.

Findings of Fact

Point 3. The most obvious concern when dealing with drug
safety is the possibility of lethal effects. Can the drug
cause death?
4. Nearly all medicines have toxic, potentially lethal
effects. But marijuana is not such a substance. There is no
record in the extensive medical literature describing a
proven, documented cannabis-induced fatality.
5. This is a remarkable statement. First, the record on
marijuana encompasses 5,000 years of human experience.
Second, marijuana is now used daily by enormous numbers of
people throughout the world. Estimates suggest that from
twenty million to fifty million Americans routinely, albeit
illegally, smoke marijuana without the benefit of direct
medical supervision. Yet, despite this long history of use


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and the extraordinarily high numbers of social smokers,
there are simply no credible medical reports to suggest
that consuming marijuana has caused a single death.
6. By contrast aspirin, a commonly used, over-the-counter
medicine, causes hundreds of deaths each year.
7. Drugs used in medicine are routinely given what is
called an LD-50. The LD-50 rating indicates at what dosage
fifty percent of test animals receiving a drug will die as
a result of drug induced toxicity. A number of researchers
have attempted to determine marijuana’s LD-50 rating in
test animals, without success. Simply stated, researchers
have been unable to give animals enough marijuana to induce
death.
8. At present it is estimated that marijuana’s LD-50 is
around
1:20,000 or 1:40,000. In layman terms this means that in
order to induce death a marijuana smoker would have to
consume 20,000 to 40,000 times as much marijuana as is
contained in onemarijuana cigarette. NIDA-supplied
marijuana cigarettes weigh approximately .9 grams. A smoker
would theoretically have to consume nearly 1,500 pounds of
marijuana within about fifteen minutes to induce a lethal
response.
9. In practical terms, marijuana cannot induce a lethal
response as a result of drug-related toxicity.
10. Another common medical way to determine drug safety is
called the therapeutic ratio. This ratio defines the
difference between a therapeutically effective dose and a
dose which is capable of inducing adverse effects.
11. A commonly used over-the-counter product like aspirin
has a therapeutic ratio of around 1:20. Two aspirins are
the recommended dose for adult patients. Twenty times this
dose, forty aspirins, may cause a lethal reaction in some
patients, and will almost certainly cause gross injury to
the digestive system, including extensive internal
bleeding.
12. The therapeutic ratio for prescribed drugs is commonly
around 1:10 or lower. Valium, a commonly used prescriptive
drug, may cause very serious biological damage if patients
use ten times the recommended (therapeutic) dose.
13. There are, of course, prescriptive drugs which have
much lower therapeutic ratios. Many of the drugs used to
treat patients with cancer, glaucoma and multiple sclerosis
are highly toxic. The therapeutic ratio of some of the
drugs used in antineoplastic therapies, for example, are
regarded as extremely toxic poisons with therapeutic ratios


Page 3

that may fall below 1:1.5. These drugs also have very low
LD-50 ratios and can result in toxic, even lethal
reactions, while being properly employed.
14. By contrast, marijuana’s therapeutic ratio, like its
LD-50, is impossible to quantify because it is so high.
15. In strict medical terms marijuana is far safer than
many foods we commonly consume. For example, eating ten raw
potatoes can result in a toxic response. By comparison, it
is physically impossible to eat enough marijuana to induce
death.
16. Marijuana, in its natural form, is one of the safest
therapeutically active substances known to man. By any
measure of rational analysis marijuana can be safely used
within a supervised routine of medical care.”

Discussion

23 thoughts on “LD50 of Cannabis

  1. The only way to kill a rat with an LD50 test on marijuana is to get a big, big lump of resin and beat the poor animal to death with it ! I speak as a Pest Controller and a medical smoker, so I know abit about toxic substances and Rats!

    Posted by Rat King | July 14, 2013, 3:17 pm
    • Why do you smoke weed with the rats? Marihauna made my son commint double homicide. My older sister, bless her heart, died from smoking an entire bag of weed in a night. Marihauna is the devil’s invention. So you smoke your marihauna and get marihauna poisoning.

      Posted by Concerned parent | September 15, 2015, 9:02 pm
      • Marijuana does not affect the the heart or the respiratory system as they do not have cannabanoid receptors. It actually protects the brain by blocking access to new brain cells (thats why the short memory does not function, although this is just temporary).

        So you are either confused with another drug or you are full of shit.

        Concerned parent my @$$

        Posted by John | December 19, 2015, 3:53 am
      • You are so full of bovine excrement we can smell it over the internet.

        First, Marijuana did not MAKE your son do anything (he was a good boy, didn’t do nuttn, I know). He may have murdered someone FOR marijuana making the little angel a thief on top of a murderer. But weed didn’t MAKE him do it. Shitty culture may have encouraged it as well as other truly awful drugs.
        Pot moves people to lovers not fighters. You may call bs but I was there so suck it. (for all legal purposes this is a work of fiction). I arrived at a bar for a little social hour, Friday evening, 9ish. Took a bar seat and ordered a drink. Just finished a first sip. There were about 12 people in the bar. This guy (linebacker beefcake high test in need of a little cut darker than walnut and just as hard) walked up and wanted to start something because I was in his seat. “get the f%&* out of my seat” “come on you pinche (I live close to Mexico) cracker, get the f%^* up” “come on, outside now” (Oh crap, I f’ed up. Went to the wrong bar and now Jack Tatum look alike is going to wad me up). I got up and at a light pace made my way to the patio as I thought that was better than fully outside. As I crossed the threshold to the patio I removed and lit the dube in my cap, sparked it and took a long drag as I turned and handed it to the bastard. It was a big cone and it took 10-15 minutes of puff puff pass, all in silence to ash it out. … … …Me: “You ready for a drink?” him: “yeah, just another minute” me: “okay”.

        Second, there are four options that would cause your daughter to die from smoking “an entire bag of weed in a night”. First, the bag somehow got stuck over her head and being stupid or to ignorant to remove it (look at her brother and Concerned Parent, intelligence isn’t a theme in your family) was unable to find her way out and asphyxiated. Second, still related to her upbringing or education, she aspirated the bag and choked on it internally. Third, someone beat her to death for smoking their “ENTIRE BAG OF WEED IN A NIGHT”, least likely option. Fourth, If her bag contained 1,500 POUNDS and she smoked it by herself in 15 MINUTES she would have hit the LD50 dose where half of subjects would die. That’s not a bag, It is about 100 30 gallon rubber made containers of weed. While there are some that will smoke a 1/4 bag in a night (7 grams) they are usually wasting over half as many smokers mention a plateau where they just can’t get any higher no matter how much they smoke. The body only has so many receptors and once they are satruated you may be high longer but there is a point you peak out. Another “true story”, wax, oil, shatter, is refined THC, 70-90% THC, 5-10 times more pure than flower. A gram was packed into pipe, that’s equivalent to 5-10 grams of flower (a good sized bag). There was nothing to light it with so an industrial soldering iron at 650 F was resourced. One expected to smoke 20 or so drags out of the pipe over the next week. To my surprise 650 degrees on a large K tip iron vaporized the entire bowl nearly instantly in the first 2 seconds of the drag. That’s 14-20 joints in 2 seconds. Was it pleasant, no. Felt like someone had kicked a hornets nest in my chest and I barely made it the 4 steps from my bathroom to my bed. Did I die? No. Get sick? No. hang over, no. kill anyone, no. Rape, steal, cheat, abuse, no, no, no, no. Cough till I blew snot out of my nose for 5 minutes, yes.

        Third, “Marihauna is the devil’s invention”. First I thought you were ignorant, now… wow, how do you get your pants on in the morning? Gen 1:12 The land produced vegetation: plants bearing seed according to their kinds and trees bearing fruit with seed in it according to their kinds. And God saw that it was good. Gen 1:29 Then God said, “I give you every seed-bearing plant on the face of the whole earth and every tree that has fruit with seed in it. They will be yours for food. Isaiah 18:4-5 4 For so the Lord said unto me, I will take my rest, and I will consider in my dwelling place like a clear heat upon herbs, and like a cloud of dew in the heat of harvest. 5 For afore the harvest, when the bud is perfect, and the sour grape is ripening in the flower, he shall both cut off the sprigs with pruning hooks, and take away and cut down the branches. Mat 15:11 The apostle Paul wrote, I know, and am persuaded by the Lord Jesus, that there is nothing unclean of itself: but to him that esteemeth anything to be unclean, to him it is unclean (it is unclean to you because you esteem to to be, but it is only to you that it is unclean. You can’t make it unclean to me because you don’t like it. I know, I like something you don’t like, I must be evil.

        I mean, oh my god. 10s of thousands die from alcohol every year, hundreds die from aspirin, eating 10 raw potatoes is more dangerous than smoking a pounds worth of pot in a day. You might be stoned for a week but you wont get sick or die.

        Posted by Twoyearsoldbutihopeyoureadthis | August 18, 2017, 1:42 am
      • Dear Concerned Parent. I am deeply sorry for your loss. nobody should experience anything like that. I am also a concerned parent – but I know for a fact that no one wakes up one day, smokes a bag of weed, gets a psychosis and decides to go on a murdering rampage. Every story has got their untold side stories – and even if he was your nice boy – perhaps you should have asked him, why he went out on a killing spree. I can only say weed doesnt kill people. – people kill people. If all drugs were legal and if the states who sell guns to people, earning money on selling guns – while fighting drugs in a so-called drug war with weapons they made tax money with while selling those guns to the drug king pins – would put all the tax money they would receive out of the legalisation of drugs and put it into educational systems where people would be wise enough to not try everything they may do, than we would not be having the problems, we are having right now. Most likely your kid might have known her limits and your boy might have known that guns do no good to people.

        Posted by cannabiphil | May 21, 2018, 12:03 pm
      • Hey, I’m really sorry to hear about your son. It must have hurt beyond what we could imagine, and I understand and respect your concern, and I can understand if you, or anyone else who can relate to you, want to place the blame on the drug they abused and ignore what I have to say. It is true that marijuana in a small portion of people, especially those who have a family history of schizophrenia, can cause psychosis which is associated with delusion which can possibly lead to violent behavior in distressed individuals. It is also possible that the marijuana, if it is street weed, had an adulterant in it, in particular one known as phencyclidine(pcp, angel’s dust, etc) which is a drug that’s high mimic’s psychosis and symptoms of schizophrenia, and is capable of causing far more severe symptoms than marijuana on its own. It could have also been used as a way to hype himself up before a murder that was already planned, as this is a well known use of some drugs.

        It is well known that marijuana has very different symptoms in different people, and for some people they can be negative, in which case they can stop, and if they develop an addiction (which does happen in 10% of the population that uses it) they can seek help or taper off of it if they so please. However, a large portion of the population derives great benefit from it. It unfortunately doesn’t have many studies done on it, because it is considered a schedule 1 drug, however it has been shown in several to be effective in the treatment of ptsd, pain(including neuropathic), parkinsons, epilepsy, and many many other conditions. I know I can testify to the immense benefit it had on me.

        I had severe depression for most of my life, and I wasn’t deriving any benefits from the SSRI/SNRIs I was taking. I was prescribed Lexapro for many years. I told my doctor that i don’t think I’m feeling any effect from it at all after several months went by, and he asked my parents if i looked happier, and they said yes, without knowing the harm it would have to me. And so I was set on this course for many years, and I started abusing ritalin, that was originally prescribed for my adhd. I thought that maybe this will make me feel something other than this stabbing ache of sadness I perpetually felt. I then added opiates to the mix. I had to quit them on my own several times without my parents knowing, which was a hell I don’t wish to experience again. My grades were plummeting, and I started a habit of physical self harm. I told no one about this and I tried to be as discreet about is as possible, because I knew my parents wouldn’t take it well and the attitude my parents instilled in me was to just push through the pain and do whatever it takes to get to my goal. I started using effexor with lexapro, and I derived no benefit, except this numb emotionless apathy which dominated all aspects of my life. I didn’t feel happy when I laughed or smiled. I felt more like a cue so I wouldn’t be viewed as a negative asshole who is never happy. I endured this hell, until I severely burned myself with sulfuric acid, hoping to quell a panic attack I was experiencing for over an hour, and it worked, at the cost of my body. I now have scars on my right foot and both my hands and arms.

        Here is where I decided to try something new out of desperation. I did my research, and I thought that I could try marijuana as a last ditch effort. I never tried it before this moment. I’ve been using it for several months now, and my grades have gone up, and Im not addicted to anything anymore. I haven’t felt the need to harm myself. I don’t use it for very extended periods and take frequent breaks, but it arguably saved my life.

        When people hear stories of marijuana making people go crazy and murder or steal, they don’t realize that they are doing a disservice to the many people who’s lives would be saved by it. Politicians will stick to a story like this to keep it illegal, since most of what we have about it is anecdotal evidence unfortunately. However, cases like this are very rare, unless its vehicular manslaughter if he was driving while high.

        As for your sister, I’m really sorry that happened, but what most likely happened was that she was on another drug, like opiates, and smoked the marijuana with it, or the marijuana itself was laced with, for example, fentanyl, a synthetic opioid about 20-30 times as strong as heroin, and she didn’t know. Or, she suffered monoxide poisoning, although that would take a ridiculous amount of marijuana. There simply isn’t a way for marijuana to kill you at the normally used, and even excessive, doses.

        I wish you the best of luck, and hope you’re doing better.

        Posted by psych0 | August 27, 2019, 7:55 pm
      • By the way, TWOYEARSOLBUTIHOPEYOUREADTHIS can go fuck himself. Miracle the mods let that one through.

        Posted by psych0 | August 27, 2019, 8:04 pm
  2. The federal government estimates the death toll of tobacco is 480,000 per year.

    Posted by Lynn Dorn | April 9, 2014, 3:44 pm
  3. The LD-50 tests I’ve seen all seem to focus on the amount of cannabis that must be smoked. Obviously, the body would simply pass out long before anything even remotely close to an LD-50 point was reached.

    But what about eating it in a concentrated form – say, in the form of hashish or hash oil? A huge amount of either of those could theoretically be ingested before their effects made continuing impossible.

    Posted by Etienne Regaj | September 30, 2015, 11:33 am
    • Hash oil can only be made to a maximum of 100% THC, whereas good marijuana is typically around 25%. So you would still have to ingest 375 pounds of 100% pure THC oil to reach the toxicity point. I don’t know about you but if I ingested 375 pounds of anything in 15 minutes I would die. Do some research people.

      Posted by Hunter Baker | February 19, 2016, 4:34 pm
      • Don’t forget you would have to buy that much and Idk about you but 375lbs of concentrates is far beyond most peoples ability to purchase at once XD

        Posted by Sean LeBlanc | September 30, 2017, 7:36 pm
      • Sorry to correct you here, Hunter Baker. THC is a crystal and not an oil. If you have an oil it is always a solution

        Posted by cannabiphil | May 21, 2018, 11:49 am
      • What cannabiphil said is technically speaking correct, but in practical terms is not very accessible. the closest thing on the market we have to 100% thc is called shatter, which is a fairly solid material, with the consistency of taffy, and when melted forms an oily liquid.

        Posted by adawwg | August 27, 2019, 7:59 pm
  4. 40,000 (large estimate for LD-50) x .9 grams (normal 15 minute dose) = 79 pounds (not 1500 pounds as claimed). It would still be a physical impossibility to achieve an overdose.

    Posted by Christopher H. Lawson | May 18, 2016, 9:53 am
  5. The LD-50 ratio is 40000:1. 40000 x the standard dose (.9 grams) = 36000 grams = 36 kilograms = 79.2 pounds.
    This is still impossible to consume within fifteen minutes but it is NOT “nearly 1,500 pounds”. Young’s math is wrong.

    Posted by Christopher H. Lawson | May 19, 2016, 6:19 am
  6. My back of the envelope calculations using .2 gm 100%THC as a base dose* yield 4-8 Kilograms as the LD50.

    Still and impossible amount to ingest, it would begin to make you physically(mechanically) ill trying.

    *5 people on a 1 gm bowl (20%THC) vs. the studies 1 person

    Posted by Charles Barnard | September 20, 2017, 2:27 pm
  7. I am quite sad they just assumed and pretty much helped perpetuate a rumor/troll….

    Posted by Virgil Mihalkovic | January 3, 2018, 1:17 pm
  8. So THC is not toxic, at least not really…

    Best regards from Switzerland,
    Sara

    Posted by Sara Hofmann | May 20, 2018, 7:18 am

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