More Good News on THC and Cancer

http://blog.mpp.org/research/more-good-news-on-thc-and-cancer/11182009/

More Good News on THC and Cancer

by Bruce Mirken

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Bruce Mirken

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For some time we’ve been pointing out the massive pile of evidence that THC and other cannabinoids have potential as anticancer drugs. A new study out of Thailand demonstrates that THC can fight cholangiocarcinoma – cancer of the bile duct. This is a rare but deadly form of cancer, with only 30 percent of patients still alive after five years, according to the  Cholangiocarcinoma Foundation. Based on these new lab results, the Thai researchers conclude, “THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.”

http://www.ncbi.nlm.nih.gov/pubmed/19916793?itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum&ordinalpos=6

The Dual Effects of Delta(9)-Tetrahydrocannabinol on Cholangiocarcinoma Cells: Anti-Invasion Activity at Low Concentration and Apoptosis Induction at High Concentration.

Leelawat S, Leelawat K, Narong S, Matangkasombut O.

Faculty of Pharmacy, Rangsit University, Patumthani, Thailand,1.

ABSTRACT Currently, only gemcitabine plus platinum demonstrates the considerable activity for cholangiocarcinoma. The anticancer effect of Delta (9)-tetrahydrocannabinol (THC), the principal active component of cannabinoids has been demonstrated in various kinds of cancers. We therefore evaluate the antitumor effects of THC on cholangiocarcinoma cells. Both cholangiocarcinoma cell lines and surgical specimens from cholangiocarcinoma patients expressed cannabinoid receptors. THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis. THC also decreased actin polymerization and reduced tumor cell survival in anoikis assay. pMEK1/2 and pAkt demonstrated the lower extent than untreated cells. Consequently, THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.

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